品牌 |
Leading Biology |
貨號 |
LM20529 |
產(chǎn)品分類 |
單克隆抗體 |
研究領(lǐng)域 |
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產(chǎn)品概述 |
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
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形式 |
KID (KNSL4; kinesin-like DNA-binding protein) is a member of the kinesin family that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis (1). KID colocalizes with mitotic chromosomes and is enriched in the kinetochore at anaphase. It might play a role in regulating the chromosomal movement along microtubules during mitosis. The N-terminal region of KID shares greater than 35% sequence homology with the motor domains of other kinesins. The C-terminal domain has limited but significant homology to NOD, a Drosophila protein and member of the kinesin family. KID also contains a putative nuclear localization signal (2). It was demonstrated that SIAH, a human homologue of the Drosophila seven in absentia (Sina), is involved in the degradation of KID via the ubiquitin-proteasome pathway (3).
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濃度 |
A synthetic peptide corresponding to residues on the N-terminus of KID was used as an immunogen. |
純度 |
Rabbit |
試劑準(zhǔn)備 |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
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復(fù)溶 |
1. Song J, et al. Genomics 52(3):374-7, 1998<br>2. Tokai N, et al. EMBO J. 15(3):457-67. 1996<br>3. Germani A, et al. Oncogene 19(52):5997-6006, 2000<br>
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儲存條件 |
Human
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儲存溶液 |
Kinesin-like protein KIF22, Kinesin-like DNA-binding protein, Kinesin-like protein 4, KIF22, KID, KNSL4
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應(yīng)用 |
WB~~1:1000~5000
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產(chǎn)品描述 |
Function
Kinesin family that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA.
Cellular_Location
Nucleus. Cytoplasm, cytoskeleton
Tissue_Location
Expressed in bone, cartilage, joint capsule, ligament, skin, and primary cultured chondrocytes
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數(shù)量 |
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