品牌 |
Leading Biology |
貨號 |
LM20512 |
產(chǎn)品分類 |
單克隆抗體 |
研究領(lǐng)域 |
|
產(chǎn)品概述 |
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
|
形式 |
This gene encodes the integrin alpha X chain protein.Integrins are heterodimeric integral membrane proteins composed ofan alpha chain and a beta chain. This protein combines with thebeta 2 chain (ITGB2) to form a leukocyte-specific integrin referredto as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2complex seems to overlap the properties of the alpha M beta 2integrin in the adherence of neutrophils and monocytes tostimulated endothelium cells, and in the phagocytosis of complementcoated particles.
|
濃度 |
This ITGAX/CD11c antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 246-274 amino acids from the N-terminal region of human ITGAX/CD11c. |
純度 |
Mouse |
試劑準備 |
Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
|
復(fù)溶 |
Van Brussel, I., et al. J. Immunol. Methods 362 (1-2), 168-175 (2010) :
Chen, X., et al. Proc. Natl. Acad. Sci. U.S.A. 107(33):14727-14732(2010)
Lindsay, R.W., et al. J. Immunol. 185(3):1513-1521(2010)
Kraus, T.S., et al. Am. J. Clin. Pathol. 134(2):271-277(2010)
Quist, S.R., et al. Acta Derm. Venereol. 90(4):429-430(2010)
|
儲存條件 |
Human
|
儲存溶液 |
Integrin alpha-X, CD11 antigen-like family member C, Leu M5, Leukocyte adhesion glycoprotein p150, 95 alpha chain, Leukocyte adhesion receptor p150, CD11c, ITGAX, CD11C
|
應(yīng)用 |
WB~~1:500~2000
|
產(chǎn)品描述 |
Function
Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.
Cellular_Location
Membrane; Single-pass type I membrane protein
Tissue_Location
Predominantly expressed in monocytes and granulocytes
|
數(shù)量 |
|