品牌 |
Leading Biology |
貨號(hào) |
LM20507 |
產(chǎn)品分類(lèi) |
單克隆抗體 |
研究領(lǐng)域 |
|
形式 |
Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility.
|
純度 |
Rat |
復(fù)溶 |
Suzuki S.,et al.EMBO J. 9:757-763(1990).
Hogervorst F.,et al.EMBO J. 9:765-770(1990).
Tamura R.N.,et al.J. Cell Biol. 111:1593-1604(1990).
Pulkkinen L.,et al.Lab. Invest. 76:823-833(1997).
Iacovacci S.,et al.Mamm. Genome 8:448-450(1997).
|
儲(chǔ)存條件 |
Human
|
儲(chǔ)存溶液 |
Integrin beta-4, GP150, CD104, ITGB4
|
應(yīng)用 |
IHC-Fr, IHC-P (20 μg/ml),
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產(chǎn)品描述 |
Function
Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility.
Cellular_Location
Cell membrane; Single-pass type I membrane protein. Cell membrane; Lipid-anchor. Cell junction, hemidesmosome. Note=Colocalizes with DST at the leading edge of migrating keratinocytes
Tissue_Location
Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoform beta-4D is also expressed in colon and placenta. Isoform beta-4E is also expressed in epidermis, lung, duodenum, heart, spleen and stomach
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數(shù)量 |
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