Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
純度
Mouse
復(fù)溶
Clin Immunol. 2009 Jun;131(3):472-80. Am J Med Genet B Neuropsychiatr Genet. 2009 Dec 5;150B(8):1147-51.
儲(chǔ)存條件
Human
儲(chǔ)存溶液
Integrin alpha-4, CD49 antigen-like family member D, Integrin alpha-IV, VLA-4 subunit alpha, CD49d, ITGA4, CD49D
應(yīng)用
E~~1/10000
WB~~1/500 - 1/2000
FC~~1/200 - 1/400
產(chǎn)品描述
Function
Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha- 4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha- 4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells.
Cellular_Location
Membrane; Single-pass type I membrane protein