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全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號(hào) |
LM20389 |
產(chǎn)品分類 |
單克隆抗體 | 研究領(lǐng)域 |
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產(chǎn)品概述 |
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
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形式 |
Gelsolin is a calcium regulated actin binding protein. Gelsolin is a regulator of actin filament assembly and disassembly and consists of six homologous subdomains (S1-S6). When C-terminal tail (S6) is bound to calcium ion, it straightens and exposes actin binding sites located on S2s helices, leading to Gelsolin actin-serving activity (1). Gelsolin is inhibited by phosphatidylinositol (4,5)-bisphosphate (PIP2), where PIP2 will bind to S1, S2, and S3 sites. Gelsolin is involved in podosome formation and has been linked to inhibition of apoptosis by preventing release of cytochrome C (2).
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濃度 |
A synthetic peptide corresponding to residues in the N-terminal region of human Gelsolin was used as immunogen. |
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純度 |
Rabbit |
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試劑準(zhǔn)備 |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
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復(fù)溶 |
1. Sun, H et al. J Biol Chem 274 (47): 33179<br>2. Koya, R, et al. J Biol Chem 275 (20): 15343-15349, 2000.<br>
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儲(chǔ)存條件 |
Human
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儲(chǔ)存溶液 |
Gelsolin, AGEL, Actin-depolymerizing factor, ADF, Brevin, GSN
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應(yīng)用 |
WB~~1:5000~20000
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產(chǎn)品描述 |
Function
Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.
Cellular_Location
Isoform 2: Cytoplasm, cytoskeleton.
Tissue_Location
Phagocytic cells, platelets, fibroblasts, nonmuscle cells, smooth and skeletal muscle cells
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數(shù)量 |
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