品牌 |
Leading Biology |
貨號 |
LM20354 |
產品分類 |
單克隆抗體 |
研究領域 |
|
形式 |
Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface- localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis.
|
濃度 |
Human FLNA |
純度 |
Mouse |
復溶 |
Gorlin J.B.,et al.J. Cell Biol. 111:1089-1105(1990).
Patrosso M.C.,et al.Genomics 21:71-76(1994).
Chen E.Y.,et al.Hum. Mol. Genet. 5:659-668(1996).
Li J.,et al.Mol. Cell. Proteomics 9:2517-2528(2010).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
|
儲存條件 |
Human
|
儲存溶液 |
Filamin-A, FLN-A, Actin-binding protein 280, ABP-280, Alpha-filamin, Endothelial actin-binding protein, Filamin-1, Non-muscle filamin, FLNA, FLN, FLN1
|
應用 |
IHC-P (5 μg/ml), WB (1:500-1:1000),
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產品描述 |
Function
Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface- localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis.
Cellular_Location
Cytoplasm, cell cortex. Cytoplasm, cytoskeleton
Tissue_Location
Ubiquitous.
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數量 |
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