品牌 |
Leading Biology |
貨號(hào) |
LM20283 |
產(chǎn)品分類 |
單克隆抗體 |
研究領(lǐng)域 |
|
形式 |
Initiates the endoplasmic reticulum-associated degradation (ERAD) that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. Catalyzes the first mannose trimming step, from Man9GlcNAc2 to Man8GlcNAc2 (PubMed:25092655). Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle.
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純度 |
Mouse |
復(fù)溶 |
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Deloukas P.,et al.Nature 414:865-871(2001).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
|
儲(chǔ)存條件 |
Human
|
儲(chǔ)存溶液 |
ER degradation-enhancing alpha-mannosidase-like protein 2, EDEM2, C20orf31, C20orf49
|
應(yīng)用 |
IHC-P (2.5 μg/ml)
|
產(chǎn)品描述 |
Function
Initiates the endoplasmic reticulum-associated degradation (ERAD) that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. Catalyzes the first mannose trimming step, from Man9GlcNAc2 to Man8GlcNAc2 (PubMed:25092655). Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle.
Cellular_Location
Secreted. Endoplasmic reticulum lumen.
Tissue_Location
Expressed ubiquitously in all tissues tested with slightly higher levels detected in small intestine and peripheral blood leukocytes and weakest levels in brain and skeletal muscle.
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數(shù)量 |
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