全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號(hào) |
LM20242 |
產(chǎn)品分類 |
單克隆抗體 | 研究領(lǐng)域 |
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產(chǎn)品概述 |
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
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形式 |
The human type II Cytokeratin 6 (CK6) is expressed in a heterogeneous array of epithelial tissues under normal conditions, but is better known for its strong induction in stratified epithelia that feature an enhanced cell proliferation rate or abnormal differentiation. CK6a is clearly the dominant CK6 isoform in skin tissue samples and cultured epithelial cell lines and that the various isoforms are differentially regulated within and between epithelial tissue types. Our findings have direct implications for an understanding of the regulation and function of CK6 during hyperproliferation in stratified epithelia and the search for disease-causing mutations in CK6 sequences in the human population. keratins show a complex regulation with constitutive and inducible components in several stratified epithelia, including the oral mucosa and skin (1). CK6a show a complex regulation with constitutive and inducible components in several stratified epithelia, including the oral mucosa and skin. Studies demonstrate an essential structural role for CK6 isoforms in the oral mucosa, and implicate filiform papillae as being the major stress bearing structures in dorsal tongue epithelium (2).
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濃度 |
A synthetic peptide corresponding to residues on the N-terminus of human Cytokeratin 6 was used as an immunogen. This antibody is predicted to detect CK-6a, CK-6b and CK-6c |
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純度 |
Rabbit |
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試劑準(zhǔn)備 |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
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復(fù)溶 |
1. Takahashi K, et al. J Biol Chem 270(31):18581-92, 1995<br>2. Wong, P et al. J Cell Biol 150(4):921-8, 2000<br>
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儲(chǔ)存條件 |
Human
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儲(chǔ)存溶液 |
Keratin, type II cytoskeletal 6A, Cytokeratin-6A, CK-6A, Cytokeratin-6D, CK-6D, Keratin-6A, K6A, Type-II keratin Kb6, Hom s 5, KRT6A, K6A, KRT6D
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應(yīng)用 |
WB~~1:10000~50000
IHC~~1:250
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產(chǎn)品描述 |
Function
Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair.
Tissue_Location
Constitutively expressed in distinct types of epithelia such as those in oral mucosa, esophagus, papillae of tongue and hair follicle outer root sheath
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數(shù)量 |
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| 選擇 | 品牌 | 貨號(hào) | 產(chǎn)品名稱 | 規(guī)格 | 分類 | 研究領(lǐng)域 | 說明書 | 數(shù)量 | 目錄價(jià) | |
| 1 | Swant | 2D7 | monoclonal anti-Glutamate antibody | 200 μl | 單克隆抗體 | Antibodies against neurotransmitters |
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￥5096.00 | 訂購(gòu) 詢價(jià) | |
| 2 | Leading Biology | LM21248 | Anti-CD36 Antibody (Rabbit Monoclonal antibody) | 100 ul | 單克隆抗體 | Chondrogenesis Markers |
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￥4950.00 | 訂購(gòu) 詢價(jià) | |
| 3 | Swant | 288 | Monoclonal antibody to endothelial cells. | 單克隆抗體 |
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￥3243.00 | 訂購(gòu) 詢價(jià) | |||
| 4 | Swant | 345 | Monoclonal antibody to rat pyramidal cells. | 200 μl | 單克隆抗體 | Miscellaneous antibodies |
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￥3243.00 | 訂購(gòu) 詢價(jià) | |
| 5 | Swant | 77 | mouse monoclonal antibody against rat angiotensinogen | 200 μl | 單克隆抗體 | Antibodies against components of the renin-angiotensin system |
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￥4015.00 | 訂購(gòu) 詢價(jià) | |
| 6 | Swant | 3A12 | monoclonal anti-GABA antibody | 200 μl | 單克隆抗體 | Antibodies against neurotransmitters |
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￥5096.00 | 訂購(gòu) 詢價(jià) |
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