全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
LM20193 |
產(chǎn)品分類 |
單克隆抗體 | 研究領(lǐng)域 |
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形式 |
Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (PubMed:23407391). CLDN1 acts as a coreceptor for HCV entry into hepatic cells.
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純度 |
Mouse |
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復(fù)溶 |
Swisshelm K.L.,et al.Gene 226:285-295(1999).
Mitic L.M.,et al.Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
Halford S.,et al.Cytogenet. Cell Genet. 88:217-217(2000).
Kraemer F.,et al.Hum. Genet. 107:249-256(2000).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
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儲存條件 |
Human
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儲存溶液 |
Claudin-1, Senescence-associated epithelial membrane protein, CLDN1, CLD1, SEMP1
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應(yīng)用 |
IHC-P (5 μg/ml)
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產(chǎn)品描述 |
Function
Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (PubMed:23407391). CLDN1 acts as a coreceptor for HCV entry into hepatic cells.
Cellular_Location
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein
Tissue_Location
Strongly expressed in liver and kidney. Expressed in heart, brain, spleen, lung and testis
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數(shù)量 |
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| 選擇 | 品牌 | 貨號 | 產(chǎn)品名稱 | 規(guī)格 | 分類 | 研究領(lǐng)域 | 說明書 | 數(shù)量 | 目錄價 | |
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| 2 | Leading Biology | LM21248 | Anti-CD36 Antibody (Rabbit Monoclonal antibody) | 100 ul | 單克隆抗體 | Chondrogenesis Markers |
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| 5 | Swant | 77 | mouse monoclonal antibody against rat angiotensinogen | 200 μl | 單克隆抗體 | Antibodies against components of the renin-angiotensin system |
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