品牌 |
Leading Biology |
貨號 |
LM20165 |
產(chǎn)品分類 |
單克隆抗體 |
研究領域 |
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產(chǎn)品概述 |
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
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形式 |
This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments. ;
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純度 |
Mouse |
復溶 |
1. Am J Pathol. 2012 Aug;181(2):487-98. 2. J Korean Med Sci. 2011 May;26(5):647-53.
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儲存條件 |
Human
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儲存溶液 |
Homeobox protein CDX-1, Caudal-type homeobox protein 1, CDX1
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應用 |
E~~1/10000
WB~~1/500 - 1/2000
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產(chǎn)品描述 |
Function
Could play a role in the terminal differentiation of the intestine.
Cellular_Location
Nucleus.
Tissue_Location
Intestinal epithelium.
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數(shù)量 |
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