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全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號(hào) |
LM20125 |
產(chǎn)品分類 |
單克隆抗體 | 研究領(lǐng)域 |
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產(chǎn)品概述 |
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
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形式 |
Required for high-level Shh responses in the developing neural tube. Together with BROMI, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling (By similarity). Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160'.
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濃度 |
Purified His-tagged CCRK protein was used to produced this monoclonal antibody. |
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純度 |
Mouse |
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試劑準(zhǔn)備 |
Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
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復(fù)溶 |
Liu Y., et al. J. Biol. Chem. 279:4507-4514(2004).
Wang L.Y., et al. Oncogene 31:2907-2918(2012).
Qiu H., et al. Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
Ota T., et al. Nat. Genet. 36:40-45(2004).
Humphray S.J., et al. Nature 429:369-374(2004).
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儲(chǔ)存條件 |
Human
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儲(chǔ)存溶液 |
Cyclin-dependent kinase 20, CDK-activating kinase p42, CAK-kinase p42, Cell cycle-related kinase, Cell division protein kinase 20, Cyclin-dependent protein kinase H, Cyclin-kinase-activating kinase p42, CDK20, CCRK, CDCH
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應(yīng)用 |
WB~~1:1000
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產(chǎn)品描述 |
Function
Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling (By similarity). Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160'.
Cellular_Location
Nucleus. Cytoplasm. Cell projection, cilium
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數(shù)量 |
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