品牌 |
Leading Biology |
貨號(hào) |
LM20063 |
產(chǎn)品分類 |
單克隆抗體 |
研究領(lǐng)域 |
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產(chǎn)品概述 |
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
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純度 |
Mouse |
復(fù)溶 |
1. J Biol Chem. 2010 Mar 26;285(13):9770-9. 2. Pharmacogenomics J. 2010 Feb 16. 3. J Int Med Res. 2009 Nov-Dec;37(6):1868-76.
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儲(chǔ)存條件 |
Human, Mouse
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儲(chǔ)存溶液 |
Apoptosis regulator Bcl-2, BCL2
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應(yīng)用 |
FC~~1/200 - 1/400
IF~~1/200 - 1/1000
IHC~~1/500 - 1/2000
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產(chǎn)品描述 |
Function
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).
Cellular_Location
Mitochondrion outer membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein
Tissue_Location
Expressed in a variety of tissues.
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數(shù)量 |
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