全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
LM20018 |
產(chǎn)品分類 |
單克隆抗體 | 研究領(lǐng)域 |
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產(chǎn)品概述 |
Store at +4°C or at -20°C.
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濃度 |
Mouse anti-SLP-76 antibody, clone SLP-76/03 recognises the SH2 domain-containing leucocyte protein, also known as SLP-76 or Lymphocyte cytosolic protein 2. SLP-76 is a ~76 kDa tyrosine phosphoprotein, expressed primarily by T lymphocytes and cells of the myeloid lineage.SLP-76 is one of several adaptor proteins assisting with TCR-mediated signal transduction, through GRB2 binding, functioning as a substrate for the protein-tyrosine kinase ZAP-70 and thus playing a crucial role in both T cell ontogeny and activation. Other molecules that associate with SLP-76 include phospholipase C (PLC)–gamma, Vav, Nck and fyn binding protein. |
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純度 |
Mouse |
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復(fù)溶 |
1. Di Bartolo V <i>et al.</i> (2007) A novel pathway down-modulating T cell activation involves HPK-1-dependent recruitment of 14-3-3 proteins on SLP-76.</br>J Exp Med. 204 (3): 681-91. 2. Brockmeyer, C. <i>et al.</i> (2011) T cell receptor (TCR)-induced tyrosine phosphorylation dynamics identifies themis as a new TCR signalosome component.</br>J Biol Chem. 286: 7535-47. 3. Lasserre, R. <i>et al.</i> (2011) Release of serine/threonine-phosphorylated adaptors from signaling microclusters down-regulates T cell activation.</br>J Cell Biol. 195 (5): 839-53. 4. Lasserre, R. <em>et al.</em> (2010) Ezrin tunes T-cell activation by controlling Dlg1 and microtubule positioning at the immunological synapse.</br>EMBO J. 29: 2301-14. 5. Paster, W. <i>et al.</i> (2013) GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development.</br>J Immunol. 190 (7): 3749-56.1. Bonilla, F.A. <i>et al.</i> (2000) Adapter proteins SLP-76 and BLNK both are expressed by murine macrophages and are linked to signaling via Fcgamma receptors I and II/III.</br>Proc Natl Acad Sci U S A. 97 (4): 1725-30.
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儲存條件 |
Human
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儲存溶液 |
Lymphocyte cytosolic protein 2, SH2 domain-containing leukocyte protein of 76 kDa, SLP-76 tyrosine phosphoprotein, SLP76, LCP2
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數(shù)量 |
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