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Mirusbio

Mirus被公認(rèn)為是核酸研究試劑開發(fā)的引領(lǐng)者，其許多杰出成就受到世界的公認(rèn)。首先研發(fā)出siRNA轉(zhuǎn)染試劑，作為世界上最早開發(fā)的高效、低細(xì)胞毒性轉(zhuǎn)染試劑的公司之一， 向市場(chǎng)推出“一步法”核酸標(biāo)記技術(shù)以及獨(dú)特的小分子RNA，如microRNA標(biāo)記技術(shù)等。

Internationally recognized gene therapy specialist, Jon Wolff, along with his colleagues James Hagstrom and Vladimir Budker founded the company in 1995, based on research they performed at the University of Wisconsin-Madison.Mirus was founded on the principle that non-viral (i.e. plasmid DNA based) methods offer distinct advantages over viral methods of gene transfer. Our initial breakthrough in 1996 came with the development of a new type of transfection reagent that combined high efficiency delivery with low cellular toxicity: TransIT?-LT1 (Low Toxicity) Reagent remains the “gold standard” for broad-based gene delivery applications.

Following this path, Mirus continued the development of a wide range of non-viral delivery technologies using proteins, polymers, and lipids in conjunction with novel chemistries that provided unique nucleic acid delivery capabilities. In 2001, our scientists applied the fundamentals of delivery to the emerging field of RNA interference and introduced the first transfection reagent specifically designed to deliver siRNA with the highest efficiencies: TransIT-TKO? Transfection Reagent.

While developing and commercializing the most relied upon transfection reagents, our commitment to the research community reached beyond delivery technologies, offering scientists tools from our bench: The Label IT? non-enzymatic nucleic acid labeling, a method of choice for studies of intracellular nucleic acid tracking. The Label IT? technology employs proprietary chemistry to covalently attach labeling molecules to DNA and RNA. This simple one-step process is faster and more robust than traditional multi-step enzymatic labeling, and can be used for intracellular tracking, chromosome analysis, and microarray labeling.With an understanding that some cell types were resistant to chemical transfection, in 2008 Mirus researchers developed and introduced: Ingenio? Electroporation Solutions, a method that can be used on any conventional device.

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