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System Biosciences

System Biosciences,簡(jiǎn)稱SBI，美國(guó)加州灣區(qū)新成立的生技公司，致力于獨(dú)特、創(chuàng)新生物技術(shù)之開(kāi)發(fā)，以研發(fā)利于基因及蛋白質(zhì)功能鑒定、研究之嶄新方法和工具為宗旨。 現(xiàn)階段研發(fā)重心為RNA干擾（RNAi）研究之相關(guān)工具。System Biosciences （SBI） 致力于開(kāi)發(fā)獨(dú)特、革新的技術(shù)，為客戶研究蛋白組學(xué)和基因組學(xué)功能提供研究工具。SBI 是專業(yè)的慢病毒產(chǎn)品公司，提供基于慢病毒.

System Biosciences (SBI) develops innovative research tools for Vector delivery technologies, MicroRNA research, Exosome research, and Genome Engineering tools, including the CRISPR-Cas9 SmartNuclease? system and PrecisionX? HR targeting vectors. 

Highlights: 

Vector Technologies: 

? Powerful lentivector systems 

? One-step transfection piggyBac transposons 

? Single-copy gene additions with phiC31 integrase vectors 

? Sustained expression without integration with Minicircle DNA plasmids 

Exosome Research Tools: 

? Isolate exosomes with ExoQuick and ExoQuick-TC 

? Exo-Flow- Immunopurify exosomes on magentic beads and anlayze by FACS 

? Culture cells in exosome-depleted FBS

 ? Verify exosome recovery with antibodies 

? Quantitate exosomes with ELISAs 

Genome Engineering: 

? RNA-guided Cas9 SmartNuclease system 

? Fast and efficient mutation correction / gene editing 

? HR donor vectors for knock-in, knock-out & tagging 

? High-throughput, targeted integration with PinPoint technology 

Stem Cell Research: 

? iPSC reprogramming systems 

? Growth factors and media 

? Pluripotency confirmation kits and antibodies 

? iPS celllines, normal and disease models 

? Promoter lineage reporters in lentivectors 

Non-coding RNA: 

? LncRNA qPCR profiling kits 

? miRNome and OncoMir qPCR profiling systems 

? Lenti-miR Precursor clone libraries – arrayed and pooled 

? miRZip anti-miR clones for stable miRNA inhibition Exo-NGS 

Custom Service: 

? Provide serum, tissue culture media, or other patient biofluids to SBI 

? SBI isolates exosomes, purifies RNA and generates high quality NGS libraries 

? Sequencing performed using Illumina MiSeq and HiSeq platforms 

? Comprehensive data analysis, including generation of heat maps and top hits, provided 

? NGS data loaded onto a custom UCSC Genome Browser for convenient viewing.

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